20 February 2026

All Mewgenics Bosses in Order (And Their Locations)

By newsgame

Edmund McMillen and Tyler Glaiel’s Mewgenics is a pure nostalgia bomb, rightfully following the legacy of these popular indie creators. A huge part of this roguelike is facing a variety of enemies, and because the game is made up of several acts, players will naturally want to know all the small and big foes they’ll run into. For that reason, this guide explains all the bosses in Mewgenics, including secrets, invaders, and event-exclusive mobs.

Full Mewgenics Soundtrack (Complete Songs List)

Explore all the Mewgenics battle, boss fight, and radio tracks in this guide.

Mewgenics Boss Guide

Mewgenics follows a unique structure when it comes to categorizing bosses. You’ll particularly find five major types of these monsters in this game:

General Threats: Every act has a number of creatures, like Kitten, Flies, Cat Caller, etc., which you must fight at different stages to progress further.
Mini-Bosses: These are slightly harder encounters, normally around four in the first zone, with fewer appearing as you advance to new arenas.
Final Bosses: Every chapter in Mewgenics has a couple of final bosses (usually one), so you can meet around seven to eight of them throughout an entire act.
House Bosses: These invade your home on their own after you clear certain areas.
Special Bosses: Some events along the way allow you to fight these rare mobs.

All Act 1 Bosses in Mewgenics

Chapter	Mini Boss	Final Boss
The Alley	Lucy Magnus Fenrir Maisie Arthur (Special)	Radical Rat (Easy Path) Queen Hippo (Hard Path)
The Sewers	The Flushmaster Rat King	Boris
The Junkyard	Can Creeper Trampy	Chubs & Nubs
The Caves	Big Slime	One Baby Spider
The Boneyard	Mama Maggot	Dybbuk
The Throbbing Domain (Secret)	None	Throbbing King

The Throbbing Domain can only be accessed through The Boneyard map after you defeat all versions of the Act 1 house boss. To make it easier, you can check out our complete guide here.

Others from Act 1

House Boss	Location
Guillotina	This giant cat will show up at your hut to eat your cats seven days after you finish Chapter Three, including both The Caves and The Boneyard.
Guillotina 2	She’s basically Guillotina in a different form, and she pops up seven mornings after you kill the home boss.
Guillotina 3	This most terrifying version of Guillotina raids your property several days later, following the defeat of her earlier form.

Mewgenics Tips & Tricks

Looking to get the most out your cats and every run in Mewgenics? Check out our tips and tricks to help you through this creepy cat adventure.

All Act 2 Bosses in Mewgenics

Mewgenics Strategy That Lets You Win Automatically

Chapter	Mini Boss	Final Boss
The Desert	Dack Gein Morana Marshmallow Arthur (Special) Dust Devil (Special)	Gambit (Easy Path) Zodiac (Hard Path)
The Crater	Infested Pair Rocky Bobo	Crater Maker
The Bunker	Bumblefoot Lenny	Johnny
The Moon	The Abandoned Ones	The Man in the Moon
The Core	Cerberubs	The Coven
The Rift (Secret)	None	Chaos Soahc

Others from Act 2

House Boss	Location
Pyrophina	Since she’s also a House Boss like Guillotina, you’ll be able to deal with her from your place seven days after crushing The Core.
Zaratana	This second home boss is an asteroid-like turtle, and you can 1v1 it seven mornings once The Moon is completed.
Pyrophina vs Zaratana	Once you smash Zaratana, the next house boss battle (Pyrophina vs. Zaratana) will open up for you around seven in-game days later.

Who’s That Character?

Identify the silhouettes before time runs out.

Who’s That Character?

Identify the silhouettes before time runs out.

Easy (7.5s)Medium (5.0s)Hard (2.5s)Permadeath (2.5s)

All Bosses in Act 3 in Mewgenics

Chapter	Mini Boss	Final Boss
The Lab	Alice Chan Hung Draven Franklin Arthur (Special)	Spewer Stacy
Ice Age	Frostbiter The Rocksnows	Lord Bunga
The Future	Dr. Mangler Zapphauser	Hitler II
The Jurassic	Dino Lovers	Dreadnoughtus
The End	The Bloat	The Mother
The Infinite (Secret)	None	The Creator

Others from Act 3

House Boss	Location
C-800	Armed with a shotgun, this terminator cat is tough to handle. It can show up after you wrap up The Future/The End.
C-1000	As with C-800, this is the second home boss, available to 1v1 once The Future/The End is wrapped up.
Hitler III	You must solve the Act 3 puzzle before the final home boss can raid your home.