13 February 2026

How to Unlock All Acts & Areas in Mewgenics

By newsgame

Published Feb 13, 2026, 10:12 AM EST

Chris is a writer and editor with over 10 years of experience covering games and has a bachelor’s degree in History from the University of Central Lancashire. He’s mainly focused on guides, but has also written hundreds of reviews, news articles, features, and list articles. A fan of all genres, you’ll find him playing EA FC 25’s Pro Clubs most evenings, diving into the latest indie game, or patiently awaiting BioShock 4’s release. Chris’ expertise focuses on the action-RPG and shooter genres, where he strives to complete every quest and top the leaderboard in online matches.

As you grow your army of cats in Mewgenics, and they grow in strength, you’ll soon be able to push into areas further away from the comfort of your house. These new areas bring tougher enemies and more unusual scenarios, but accessing all of them isn’t as straightforward as you might think. In this guide, I’ll explain how to unlock all acts and areas in Mewgenics, so you can see every little locale the game has to offer in its zany, cat-crazed universe.

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Unlocking All Acts and Areas in Mewgenics

Down below, I’ve listed the unlock requirements for each area in Mewgenics. For the most part, these are fairly straightforward. However, there are some secret areas that require you to put a little more effort in, and revolve around beating the house bosses.

Act/ Area	Unlock Requirements
The Alley	Unlocked at the start of the game.
The Sewers	Complete a run in The Alley.
The Caves	Complete a run in The Sewers.
The Junkyard	Complete the ‘hard branch’ of The Alley.
The Boneyard	Complete a run in The Junkyard.
The Throbbing Domain (Secret)	You need to take the Throbbing Gristle from Guillotina’s first boss fight to the Wall of Flesh in the caves, and the Putrid Leach from Guillotina’s second fight to the Throbbing Artery in The Boneyard. Fight Guillotina for a third time to get her head. Equip this to one of your cats and then go to the altar in The Throbbing Domain. Sacrifice the cat with Guillotina’s head equipped.
Desert	Complete runs in The Boneyard and The Caves.
The Bunker	Complete a run in The Desert
The Core	Complete a run in The Bunker.
The Crater	Complete a run in The Desert.
The Moon	Complete a run in The Crater.
The Rift (Secret)	After clearing runs on The Moon and The Core, you’ll meet Pyrophina and Zaratana. After defeating each of those, you need to take the Burning Orb from Pyrophina and feed it to The Man on the Moon by having a cat hold it and stand in front of the boss. The Shard you get from Zaratana needs charging by killing 20 enemies with it equipped. Then take this to the Coven on the Core and use the Shard on it to insta-kill it. This will cause both Pyrophina and Zaratana to return to your house. This time, they’re battling one another as giant versions of themselves. Once one is defeated, you’ll get a collar of the surviving boss. For Pyrophina’s collar, take it to the obelisk at the end of the Moon, while Zaratana’s collar needs to go to the Core obelisk. After doing so, you’ll unlock the Rift.
The Lab	Complete runs in The Core and The Moon.
Ice Age	Complete a run in The Lab.
The Future	Complete a run in The Lab.
The Jurassic	Complete a run in Ice Age
The End	Complete a run in The Future
The Infinite	Complete runs in The Jurassic and The End.

It is possible to progress through the game and reach the end without properly engaging with both The Throbbing Domain and The Rift if you don’t want to, but unlocking each of these makes for a pretty fun side quest that’ll put your skills to the test.

It’s worth noting that it takes a serious amount of time to reach the latter stages of the game. As there’s no way to lower the difficulty, and due to the way that runs can sometimes go, you may find that just advancing through one area could take you a significant amount of time, especially if you begin to run low on cats.

As such, make sure you keep your cats with the best stats in your house so you can breed from them, and never be too afraid to experiment with the quartet of cats you take out on an adventure. If you need more help, check out our best Mewgenics tips.